Publications

 

  1. Chattopadhyay, A., O’Connor, E.C., Tingler, A.M., Helke, K.L., Engevik, M.A., Ferreira, L.M.R., 2026. MUC4-targeted CAR-T cells restrain chemotherapy-resistant colorectal cancer. bioRxiv doi:10.64898/2026.02.26.708339

  2. Brim, A.D., Ferreira, L.M.R., 2026. From blind to bound: CRISPR restores IL-2 responsiveness in patient Tregs. Mol Ther, 34(3): 1301-1303

  3. Chen, T., Quinn, Z., Mishra, K., O’Connor, E.C., Silver, S.E., Zhang, Y., Valencia, M.J., Mei, Y., Behmoaras, J., Ferreira, L.M.R., Chatterjee, P., 2026. moPPIt: De novo generation of motif-specific and functionally active peptide binders via discrete flow matching. bioRxiv doi:10.1101/2024.07.31.606098

  4. Chattopadhyay, A., Ferreira, L.M.R., 2025. Why regulatory T cells love lactic acid. Mol Ther Methods Clin Dev 33(4): 101647

  5. Golick, L., Robinson, R.M., Reyes, L., St. Thomas, N., Klinzing, K., O’Connor, E.C., Ferreira, L.M.R., Dolloff, N.G., 2025. A superantigen-based MHC class II-targeted cancer immunotherapy for the treatment of acute myeloid leukemia. Blood Cancer J 15: 198

  6. Hamilton, F.W., Ferreira, L.M.R., 2025. From rough to refined: Applying diamond standards to CAR Treg development. Mol Ther Methods Clin Dev 33(4): 101604

  7. Boardman, D.A., Smyth, L.A., Ferreira, L.M.R., 2025. Editorial: Repurposing cancer immunotherapies for use in autoimmunity and transplantation. Front. Immunol. 16:1690655

  8. Bechi Genzano, C., Young, T., Bonami, R., Chimienti, R., Ferreira, L.M.R., Sims, E.K., Creusot, R.J., 2025. Autoimmune diabetes and targets for immunomodulation. Semin Immunol. 79: 101983

  9. Valentín-Quiroga, J., Zarauza-Santoveña, A., López-Collazo, E., Ferreira, L.M.R., 2025. Chimeric anti-HLA antibody receptor engineered human regulatory T cells suppress alloantigen-specific B cells from pre-sensitized transplant recipients. Front Immunol 16:1601385

  10. Silver, S.E., Howells, A.R., Arhontoulis, D.C., Randolph, L.N., Hyams, N.A., Barrs, R.W., Li, M., Kerr, C.M., Robino, R.A., Morningstar, J.E., Bain, J.D., Floy, M.E., Norris, R.A., Bao, X., Ruddy, J.M., Palecek, S.P., Ferreira, L.M.R., Lian, X.L., Mei, Y., 2025. Hypoimmunogenic hPSC-derived cardiac organoids for immune evasion and heart repair. bioRxiv doi:10.1101/2025.04.09.648007

  11. Reis, F., Ferreira, L.M.R., Ortega, E., Viana, S., 2025. Nutrition and Gut Microbiota–Immune System Interplay in Chronic Diseases. Nutrients 17 (8): 1330

  12. Parent, A.V., Agarwal, A., Alvarez-Dominguez, J.R., Arrojo e Drigo, R., Atkinson, M.A., Brehm, M.A., Ferreira, L.M.R., Kaestner, K.H., Kravets, V., Niland, J.C., O’Meally, D., Rouse, L., Russ, H.A., Stabler, C.L., Kaddis J.S., 2025. Closing the gap between vision and victory in type 1 diabetes: the NIDDK Human Islet Research Network (HIRN) initiative. Diabetes db250097 

  13. Gu, B., Ferreira, L.M.R., Herrera, S., Brown, L., Lieberman, J., Sherwood, R.I., Meissner, T.B., Strominger, J.L., 2025. The TEA domain transcription factors TEAD1 and TEAD3 and WNT signaling determine HLA-G expression in human extravillous trophoblasts. Proc Natl Acad Sci USA 122(12):e2425339122 

  14. Cochrane, R.W., Allen, A., Ferreira, L.M.R., 2025. Expanding the engineered Treg multiverse. Mol Ther 33(3):833-836

  15. Sytsma, B.J., Allain, V., Bourke, S., Faizee, F., Fathi, M., Berdeaux, R., Ferreira, L.M.R., Brewer, J., Li, L., Pan, F.L., Rothrock, A.G., Nyberg, W.A., Li, Z., Wilson, L.H., Eyquem, J., Pawell, R.S., 2025. Scalable intracellular delivery via microfluidic vortex shedding enhances the function of chimeric antigen receptor T-cells. Sci Rep 15: 5749

  16. Cochrane, R.W., Robino, R.A., Ferreira, L.M.R., 2025. Generation of human chimeric antigen receptor regulatory T cells. J Vis Exp (215), e67200

  17. Cochrane, R.W., Robino, R.A., Granger, B., Allen, E., Vaena, S., Romeo, M.J., de Cubas, A.A., Berto, S., Ferreira, L.M.R., 2024. High affinity chimeric antigen receptor signaling induces an inflammatory program in human regulatory T cells. Mol Ther Methods Clin Dev 32(4): 101385

  18. Barra, J.M., Robino, R.A., Castro-Gutierrez, R., Proia, J., Russ, H.A., Ferreira, L.M.R., 2024. Combinatorial genetic engineering strategy for immune protection of stem cell-derived beta cells by chimeric antigen receptor regulatory T cells. Cell Rep 43 (11):114994

  19. Wang, F., Ferreira, L.M.R., Mazzanti, A., Yu, H., Gu, B., Meissner, T.B., Li, Q., Strominger, J.L., 2024. Progesterone-mediated remodeling of the maternal-fetal interface by a PGRMC1-dependent mechanism. J Reprod Immunol 163:104244

  20. Cochrane, R.W., Fiorentino, A., Allen, E., Robino, R.A., Quiroga, J., Ferreira, L.M.R., 2024. How to test human CAR T cells in solid tumors, the next frontier of CAR T cell therapy. Methods Mol Biol 2748:243-265

  21. Zimmerman, C.M., Robino, R.A., Cochrane R.W., Dominguez, M.D., Ferreira, L.M.R., 2024. Redirecting human conventional and regulatory T cells using chimeric antigen receptors. Methods Mol Biol 2748:201-241

  22. Tennant, M.D., New, C., Ferreira, L.M.R., O’Neil, R.T., 2023. Efficient T cell adoptive transfer in lymphoreplete hosts mediated by transient Stat5 signaling. Mol Ther 31 (9), 2591-2599

  23. Ferreira, L.M.R., 2023. Conference report: Advanced Therapies Week 2023. Regen Med 18(4):297-299

  24. Skartsis, N., Muller, Y.D., Ferreira, L.M.R., 2023. Regulatory T cell homeostasis: requisite signals and implications for clinical development of biologics. Clin Immunol 246: 109201

  25. Ghobadinezhad, F., Ebrahimi, N., Mozaffari, F., Moradi, N., Beiranvand, S., Pournazari, M., Rezaei-Tazangi, F., Khorram, R., Afshinpour, M., Robino, R., Aref, A.R., Ferreira, L.M.R., 2022. The emerging role of regulatory cell-based therapy in autoimmune disease. Front Immunol 13:1075813

  26. Skartsis, N., Ferreira, L.M.R., Tang, Q., 2022. The dichotomous outcomes of TNFa signaling in CD4+ T cells. Front Immunol 13:1042622

  27. Khosravi-Maharlooei, M., Madley, R., Borsotti, C., Ferreira, L.M.R., Sharp, R.C., Brehm, M.A., Greiner, D.L., Parent, A.V., Anderson, M.S., Sykes, M., Creusot, R.J., 2022. Modeling human T1D-associated autoimmune processes. Mol Metab 56:101417

  28. Skartsis, N., Peng, Y., Ferreira, L.M.R., Nguyen, V., Ronin, E., Muller, Y.D., Vincenti, F., Tang, Q., 2021. IL-6 and TNFa drive extensive proliferation of human Tregs without compromising their lineage stability or function. Front Immunol 12:783282

  29. Ferreira, L.M.R., Muller, Y.D., 2021. CAR T-cell therapy: is CD28-CAR heterodimerization its Achilles’ heel? Front Immunol 12:766220   

  30. Muller, Y.D., Ferreira, L.M.R., Ronin, E., Ho, P., Nguyen, V., Faleo, G., Zhou, Y., Lee, K., Leung, K.K., Skartsis, N., Kaul, A.M., Mulder, A., Claas, F.H.J., Wells, J.A., Bluestone, J.A., Tang, Q., 2021. Precision engineering of an anti-HLA-A2 chimeric antigen receptor in regulatory T cells for transplant immune tolerance. Front Immunol 12:686439

  31. Muller, Y.D., Nguyen, D.P., Ferreira, L.M.R., Ho, P., Raffin, C., Valencia, R.B., Congrave-Wilson, Z., Roth, T., Eyquem, J., Van Gool, F., Marson, A., Perez, L., Wells, J.A., Bluestone, J.A., Tang, Q., 2021. The CD28-transmembrane domain mediates chimeric antigen receptor heterodimerization with CD28. Front Immunol 12:639818

  32. Gershteyn, I.M., Burov, A.A., Miao, B.Y., Morais, V.H., Ferreira, L.M.R., 2020. Immunodietica: interrogating the role of diet in autoimmune disease. Int Immunol 32 (12), 771-783

  33. Ferreira, L.M.R., Mostajo-Radji, M.A., 2020. Plasma-based COVID-19 treatments in low- and middle-income nations pose a high risk of an HIV epidemic. npj Vaccines 5, 58

  34. Watson, A., Ferreira, L.M.R., Hwang, P., Xu, J., Stroud, R., 2020. Peptide antidotes to SARS-CoV-2 (COVID-19). bioRxiv doi:10.1101/2020.08.06.238915

  35. Ferreira, L.M.R., Li, A.M., Serafim, T.L., Sobral, M.C., Alpoim, M.C., Urbano, A.M., 2020. Intermediary metabolism: An intricate network at the crossroads of cell fate and function. Biochim Biophys Acta Mol Basis Dis 1866 (10), 165887

  36. Yu, H., Rimbert, A., Palmer, A.E., Toyohara, T., Xia, Y., Xia, F., Ferreira, L.M.R., Chen, Z., Chen, T. Loaiza, N., Horwitz, N.B., Kacergis, M.C., Zhao, L., BIOS Consortium, Soukas, A.A., Kuivenhoven, J.A., Kathiresan, S., Cowan, C.A., 2019. GPR146 deficiency protects against hypercholesterolemia and atherosclerosis. Cell 179 (6), 1276-1288.e14

  37. Abreu, P.L., Ferreira, L.M.R., Cunha-Oliveira, T., Alpoim, M.C., Urbano, A.M., 2019. HSP90: A Key Player in Metal-Induced Carcinogenesis? Heat Shock Protein 90 in Human Diseases and Disorders. Heat Shock Proteins. Asea A., Kaur P. (eds), ISBN: 978-3-030-23158-3, Springer

  38. Ferreira, L.M.R., Cunha-Oliveira, T., Sobral, M.C., Abreu, P.L., Alpoim, M.C., Urbano, A.M., 2019. Impact of carcinogenic chromium on the cellular response to proteotoxic stress. Int J Mol Sci 20 (19), E4901

  39. Ferreira, L.M.R., Muller, Y.D., Bluestone, J.A., Tang, Q., 2019. Next-generation regulatory T cell therapy. Nat Rev Drug Discov 18, 749-769

  40. Carosso, G.A., Ferreira, L.M.R., Mostajo-Radji, M.A., 2019. Developing brains, developing nations: Can scientists be effective non-state diplomats? Front Educ 4, 95

  41. Carosso, G.A., Ferreira, L.M.R., Mostajo-Radji, M.A., 2019. Scientists as non-state actors of public diplomacy. Nat Hum Behav 3, 1129–1130

  42. Ferreira, L.M.R., Carosso, G.A., Duran, N.M., Bohorquez-Massud, S.V., Vaca-Diez, G., Rivera-Betancourt, L.A., Rodriguez, Y., Ordonez, D.G., Alatriste-Gonzalez, D.K., Vacaflores, A., Auza, L.G., Schuetz, C., Alvarado-Arnez, L.E., Alexander-Savino, C.V., Gandarilla, O., Mostajo-Radji, M.A., 2019. Effective participatory science education in a diverse Latin American population. Palgrave Comm 5, 11

  43. Gershteyn, I.M., Ferreira, L.M.R., 2019. Immunodietica: A data-driven approach to investigate interactions between diet and autoimmune disorders. Journal of Translational Autoimmunity 1, 100003

  44. Han, X., Wang, M., Duan, S., Franco, P.J., Kenty, J.H.R., Hedrick, P., Xia, Y., Allen, A., Ferreira, L.M.R., Strominger, J.L., Melton, D.A., Meissner, T.B., Cowan, C.A., 2019. Generation of hypoimmunogenic human pluripotent stem cells. Proc Natl Acad Sci USA 116 (21), 10441-10446

  45. Abreu, P.L., Cunha-Oliveira, T., Ferreira, L.M.R., Urbano, A.M., 2018. Hexavalent chromium, a lung carcinogen, confers resistance to thermal stress and interferes with heat shock protein expression in human bronchial epithelial cells. Biometals 31 (4), 477-487

  46. Tilburgs, T., Meissner, T.B., Ferreira, L.M.R., Mulder, A., Musunuru, K., Ye, J., Strominger, J.L., 2017. NLRP2 is a suppressor of NF-kB signaling and HLA-C expression in human trophoblasts. Biol Reprod 96 (4), 831-842

  47. Ferreira, L.M.R., Meissner, T.B., Tilburgs, T., Strominger, J.L, 2017. HLA-G: at the interface of maternal-fetal tolerance. Trends Immunol 38 (4), 272-286

  48. Ferreira, L.M.R., Tang, Q., 2017. Generating antigen-specific regulatory T cells in the fast lane. Am J Transplant 17 (4), 851-853

  49. Ferreira, L.M.R., Meissner, T.B., Mikkelsen, T.S., Mallard, W., O’Donnell, C.W., Tilburgs, T., Gomes, H.A.B., Camahort, R., Sherwood, R.I., Gifford, D.K., Rinn, J.L., Cowan, C.A., Strominger, J.L., 2016. A distant trophoblast-specific enhancer controls HLA-G expression at the maternal-fetal interface. Proc Natl Acad Sci USA 113 (19), 5364-5369

  50. Meissner, T.B., Mandal, P.K., Ferreira, L.M.R., Rossi, D.J., Cowan, C.A., 2014. Genome editing for human gene therapy. Methods Enzymol546, 273-295

  51. Mandal, P.K., Ferreira, L.M.R., Collins R., Meissner T.B., Boutwell C.L., Friesen M., Vrbanac V., Garrison B.S., Stortchevoi A., Bryder D., Musunuru K., Brand H., Tager A.M., Allen T.M., Talkowski M.E., Rossi D.J., Cowan C.A., 2014. Efficient Ablation of Genes in Human Hematopoietic Stem and Effector Cells using CRISPR/Cas9. Cell Stem Cell 15(5), 643-652

  52. Abreu, P.L., Ferreira, L.M.R., Alpoim, M.C., Urbano, A.M., 2014. Impact of hexavalent chromium on mammalian cell bioenergetics: phenotypic changes, molecular basis and potential relevance to chromate-induced lung cancer. Biometals 27(3), 409-443

  53. Ferreira, L.M.R., 2013. Gammadelta T cells: innately adaptive immune cells? Int Rev Immunol 2(3), 223-248

  54. Ferreira, L.M.R. and Mostajo-Radji, M.A., 2013. How induced pluripotent stem cells are redefining personalized medicine. Gene 520 (1), 1-6

  55. Mostajo-Radji, M.A. and Ferreira, L.M.R., 2012. Changing cell identity to create true personalized medicine. Gac Med Bol 35(2), 76-79

  56. Ferreira, L.M.R., Floriddia, E.M., Quadrato, G., Di Giovanni, S., 2012. Neural regeneration: lessons from regenerating and non-regenerating systems. Mol Neurobio. 46, 227-241

  57. Ferreira, L.M.R., Hebrant, A., Dumont, J.E., 2012. Metabolic reprogramming of the tumor. Oncogene 31(36), 3999-4011

  58. Urbano, A.M., Ferreira, L.M.R., Alpoim, M. C., 2012. Molecular and cellular mechanisms of hexavalent chromium-induced lung cancer: an updated perspective. Curr Drug Metab 13(3), 284-305

  59. Urbano, A.M., Ferreira, L.M.R., Cerveira, J.F., Rodrigues, C.F., Alpoim, M.C., 2011. DNA Damage, Repair and Misrepair in Cancer and in Cancer Therapy. DNA Repair and Human Health, Sonya Vengrova (ed.), ISBN: 978-953-307-612-6, InTech

  60. Ferreira, L.M.R., 2010. Cancer metabolism: The Warburg effect today. Exp Mol Pathol 89, 372-380